Continuous lymphoid cell lines with characteristics of B cells (bone-marrow-derived), lacking the Epstein-Barr virus genome and derived from three human lymphomas.

نویسندگان

  • G Klein
  • T Lindahl
  • M Jondal
  • W Leibold
  • J Menézes
  • K Nilsson
  • C Sundström
چکیده

Three exceptional cell lines have been tested for the presence of the Epstein-Barr virus genome by nucleic acid hybridization (complementary RNA.DNA) and Epstein-Barr virus-determined nuclear antigen tests. Two lines were derived from Swedish lymphoma cases and one from an African Burkitt-like lymphoma biopsy that was negative for Epstein-Barr virus DNA and the virus-determined nuclear antigen. All three lines apparently lacked the viral genome. Two of the three lines clearly had characteristics of B-cells (bone-marrow-derived).

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عنوان ژورنال:
  • Proceedings of the National Academy of Sciences of the United States of America

دوره 71 8  شماره 

صفحات  -

تاریخ انتشار 1974